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The movement of fluids between the intravascular and interstitial compartments, is classically described as being governed by Starling forces, leading to a small net efflux of fluid from the intravascular to the interstitial compartment. The extracellular compartment is divided into intravascular, interstitial and transcellular compartments. In healthy humans, the body is composed of approximately 60% water, distributed between intracellular and an extracellular compartments. An understanding of the physiology of body fluids is essential when considering appropriate fluid resuscitation and fluid replacement therapy in critically-ill patients.
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